Steven Truschel, Ph.D.

Steven Truschel, Ph.D.

Appointments
: Department of Medicine

Contact Information:
University of Pittsburgh
Renal/Electrolyte Division
982 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261

Telephone: 412-383-8892
Fax: 412-383-8955/8956
E-mail: stt39@pitt.edu

Education and Training:

Undergraduate:
B.S., Pennsylvania State University, University Park, PA, 1990-1994

Graduate:
Ph.D., University of Pittsburgh, Program in Cell Biology and Molecular Physiology, Pittsburgh, PA, Dr. Gerard Apodaca mentor, 1996-2003

Postdoctoral:
University of Pennsylvania, Department of Pathology, Dr. Michael Marks mentor
Carnegie Mellon University, Department of Biological Sciences, Dr. Adam Linstedt, mentor


Current Position: Research Assistant Professor, University of Pittsburgh School of Medicine, Renal-Electrolyte Division, 2015 - present
Enter the name for this tabbed section: Primary Research Articles
Truschel ST, Ruiz WG, Shulman T, Pilewski J, Sun TT, Zeidel ML, Apodaca G. Primary uroepithelial cultures. A model system to analyze umbrella cell barrier function. J Biol Chem. 1999 May 21;274(21):15020-9. Review. PubMed PMID:10329705.

Truschel ST, Wang E, Ruiz WG, Leung SM, Rojas R, Lavelle J, Zeidel M, Stoffer D, Apodaca G. Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. Mol Biol Cell. 2002 Mar;13(3):830-46. PubMed PMID: 11907265; PubMed Central PMCID: PMC99602.

Wang E, Truschel S, Apodaca G. Analysis of hydrostatic pressure-induced changes in umbrella cell surface area. Methods. 2003 Jul;30(3):207-17. PubMed PMID: 12798135.

Theos AC, Truschel ST, Raposo G, Marks MS. The Silver locus product Pmel17/gp100/Silv/ME20: controversial in name and in function. Pigment Cell Res. 2005 Oct;18(5):322-36. Review. PubMed PMID: 16162173; PubMed Central PMCID: PMC2788625.

Theos AC, Truschel ST, Tenza D, Hurbain I, Harper DC, Berson JF, Thomas PC, Raposo G, Marks MS. A lumenal domain-dependent pathway for sorting to
intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. Dev Cell. 2006 Mar;10(3):343-54. PubMed PMID: 16516837; PubMed Central PMCID: PMC1773005.

Setty SR, Tenza D, Truschel ST, Chou E, Sviderskaya EV, Theos AC, Lamoreux ML, Di Pietro SM, Starcevic M, Bennett DC, Dell'Angelica EC, Raposo G, Marks MS. BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol Biol Cell. 2007 Mar;18(3):768-80. PubMed PMID: 17182842; PubMed Central PMCID: PMC1805088.

Truschel ST, Simoes S, Setty SR, Harper DC, Tenza D, Thomas PC, Herman KE, Sackett SD, Cowan DC, Theos AC, Raposo G, Marks MS. ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane. Traffic. 2009 Sep;10(9):1318-36. doi: 10.1111/j.1600-0854.2009.00955.x. PubMed PMID: 19624486; PubMed Central PMCID: PMC2747296.

Truschel ST, Sengupta D, Foote A, Heroux A, Macbeth MR, Linstedt AD. Structure of the membrane-tethering GRASP domain reveals a unique PDZ ligand interaction that mediates Golgi biogenesis. J Biol Chem. 2011 Jun 10;286(23):20125-9. doi: 10.1074/jbc.C111.245324. PubMed PMID: 21515684; PubMed Central PMCID: PMC3121478.

Truschel ST, Zhang M, Bachert C, Macbeth MR, Linstedt AD. Allosteric regulation of GRASP protein-dependent Golgi membrane tethering by mitotic phosphorylation. J Biol Chem. 2012 Jun 8;287(24):19870-5. doi: 10.1074/jbc.M111.326256. PubMed PMID: 22523075; PubMed Central PMCID: PMC3370171.
Enter the name for this tabbed section: Review Articles
Enter the name for this tabbed section: Books and Chapters