Professor Gerard Apodaca, Ph.D.

Professor Gerard Apodaca, Ph.D.

: Departments of Medicine and Cell Biology

Director: Pittsburgh Center for Kidney Research Kidney Imaging Core

Contact Information:
University of Pittsburgh
Renal/Electrolyte Division
980 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261

Telephone: 412-383-8893
Fax: 412-383-8955/8956

Education and Training:

B.A., Rollins College, Winter Park, FL, 1979–1983

Ph.D., University of California, San Francisco, CA, Dr. James McKerrow mentor, 1983-1989

University of California, San Francisco, CA, Dr. Keith Mostov mentor, 1989-1995
Enter the name for this tabbed section: Primary Research Articles
Asahi M, Lindquist R, Fukuyama K, Apodaca G, Epstein WL, McKerrow JH. Purification and characterization of major extracellular proteinases from Trichophyton rubrum. Biochem J. 1985 Nov 15;232(1):139-44. PubMed Central PMCID: PMC1152850.

Rutka JT, Giblin JR, Apodaca G, DeArmond SJ, Stern R, Rosenblum ML. Inhibition of growth and induction of differentiation in a malignant human glioma cell line by normal leptomeningeal extracellular matrix proteins. Cancer Res. 1987 Jul 1;47(13):3515-22. PubMed PMID: 3555773.

Apodaca G, McKerrow JH. Regulation of Trichophyton rubrum proteolytic activity. Infect Immun. 1989 Oct;57(10):3081-90. PubMed PMID: 2476398; PubMed Central PMCID: PMC260773.

Apodaca G, McKerrow JH. Purification and characterization of a 27,000-Mr extracellular proteinase from Trichophyton rubrum. Infect Immun. 1989 Oct;57(10):3072-80. PubMed PMID: 2674015; PubMed Central PMCID: PMC260772.

Apodaca G, McKerrow JH. Expression of proteolytic activity by cultures of Trichophyton rubrum. J Med Vet Mycol. 1990;28(2):159-71. PubMed PMID: 1696313.

Apodaca G, Rutka JT, Bouhana K, Berens ME, Giblin JR, Rosenblum ML, McKerrow JH, Banda MJ. Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells. Cancer Res. 1990 Apr 15;50(8):2322-9. PubMed PMID: 2156617.

Casanova JE, Apodaca G, Mostov KE. An autonomous signal for basolateral sorting in the cytoplasmic domain of the polymeric immunoglobulin receptor. Cell. 1991 Jul 12;66(1):65-75. PubMed PMID: 2070419.

Banda MJ, Howard EW, Herron GS, Apodaca G. Secreted inhibitors of metalloproteinases (IMPs) that are distinct from TIMP. Matrix Suppl. 1992;1:294-8. PubMed PMID: 1480040.

Lindstedt R, Apodaca G, Barondes SH, Mostov KE, Leffler H. Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway. J Biol Chem. 1993 Jun 5;268(16):11750-7. PubMed PMID: 8505302.

Apodaca G, Aroeti B, Tang K, Mostov KE. Brefeldin-A inhibits the delivery of the polymeric immunoglobulin receptor to the basolateral surface of MDCK cells. J Biol Chem. 1993 Sep 25;268(27):20380-5. PubMed PMID: 8376395.

Apodaca G, Mostov KE. Transcytosis of placental alkaline phosphatase-polymeric immunoglobulin receptor fusion proteins is regulated by mutations of Ser664. J Biol Chem. 1993 Nov 5;268(31):23712-9. PubMed PMID: 8226896.

Apodaca G, Katz LA, Mostov KE. Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes. J Cell Biol. 1994 Apr;125(1):67-86. PubMed PMID: 8138576; PubMed Central PMCID: PMC2120019.

Apodaca G, Enrich C, Mostov KE. The calmodulin antagonist, W-13, alters transcytosis, recycling, and the morphology of the endocytic pathway in Madin-Darby canine kidney cells. J Biol Chem. 1994 Jul 22;269(29):19005-13. PubMed PMID: 7913467.

Song W, Apodaca G, Mostov K. Transcytosis of the polymeric immunoglobulin receptor is regulated in multiple intracellular compartments. J Biol Chem. 1994 Nov 25;269(47):29474-80. PubMed PMID: 7961930.

Apodaca G, Bomsel M, Lindstedt R, Engel J, Frank D, Mostov KE, Wiener-Kronish J. Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: glycosylation-defective host cells are resistant to bacterial killing. Infect Immun. 1995 Apr;63(4):1541-51. PubMed PMID: 7890421; PubMed Central PMCID: PMC173187.

Apodaca G, Cardone MH, Whiteheart SW, DasGupta BR, Mostov KE. Reconstitution of transcytosis in SLO-permeabilized MDCK cells: existence of an NSF-dependent fusion mechanism with the apical surface of MDCK cells. EMBO J. 1996 Apr 1;15(7):1471-81. PubMed PMID: 8612570; PubMed Central PMCID: PMC450054.

Enrich C, Apodaca G, Mostov KE. Calmodulin regulates the intracellular trafficking in epithelial cells. Z Gastroenterol. 1996 Jun;34 Suppl 3:83-5. PubMed PMID: 8767473.

van Ooij C, Apodaca G, Engel J. Characterization of the Chlamydia trachomatis vacuole and its interaction with the host endocytic pathway in HeLa cells. Infect Immun. 1997 Feb;65(2):758-66. PubMed PMID: 9009339; PubMed Central PMCID: PMC176122.

Maples CJ, Ruiz WG, Apodaca G. Both microtubules and actin filaments are required for efficient postendocytotic traffic of the polymeric immunoglobulin receptor in polarized Madin-Darby canine kidney cells. J Biol Chem. 1997 Mar 7;272(10):6741-51. PubMed PMID: 9045707.

Kang PJ, Hauser AR, Apodaca G, Fleiszig SM, Wiener-Kronish J, Mostov K, Engel JN. Identification of Pseudomonas aeruginosa genes required for epithelial cell injury. Mol Microbiol. 1997 Jun;24(6):1249-62. PubMed PMID: 9218773.

Lavelle JP, Apodaca G, Meyers SA, Ruiz WG, Zeidel ML. Disruption of guinea pig urinary bladder permeability barrier in noninfectious cystitis. Am J Physiol. 1998 Jan;274(1 Pt 2):F205-14. PubMed PMID: 9458841.

Leung SM, Chen D, DasGupta BR, Whiteheart SW, Apodaca G. SNAP-23 requirement for transferrin recycling in Streptolysin-O-permeabilized Madin-Darby canine kidney cells. J Biol Chem. 1998 Jul 10;273(28):17732-41. PubMed PMID: 9651373.

Birder LA, Apodaca G, De Groat WC, Kanai AJ. Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. Am J Physiol. 1998 Aug;275(2 Pt 2):F226-9. PubMed PMID: 9691011.

Henkel JR, Apodaca G, Altschuler Y, Hardy S, Weisz OA. Selective perturbation of apical membrane traffic by expression of influenza M2, an acid-activated ion channel, in polarized madin-darby canine kidney cells. Mol Biol Cell. 1998 Sep;9(9):2477-90. PubMed PMID: 9725907; PubMed Central PMCID: PMC25516.

Truschel ST, Ruiz WG, Shulman T, Pilewski J, Sun TT, Zeidel ML, Apodaca G. Primary uroepithelial cultures. A model system to analyze umbrella cell barrier function. J Biol Chem. 1999 May 21;274(21):15020-9. Review. PubMed PMID:10329705.

Altschuler Y, Liu S, Katz L, Tang K, Hardy S, Brodsky F, Apodaca G, Mostov K. ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells. J Cell Biol. 1999 Oct 4;147(1):7-12. PubMed PMID: 10508850; PubMed Central PMCID: PMC2164974.

Leung SM, Rojas R, Maples C, Flynn C, Ruiz WG, Jou TS, Apodaca G. Modulation of endocytic traffic in polarized Madin-Darby canine kidney cells by the small GTPase RhoA. Mol Biol Cell. 1999 Dec;10(12):4369-84. PubMed PMID: 10588664; PubMed Central PMCID: PMC25764.

Jou TS, Leung SM, Fung LM, Ruiz WG, Nelson WJ, Apodaca G. Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1. Mol Biol Cell. 2000 Jan;11(1):287-304. PubMed PMID: 10637309; PubMed Central PMCID: PMC14775.

Altschuler Y, Kinlough CL, Poland PA, Bruns JB, Apodaca G, Weisz OA, Hughey RP. Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation state. Mol Biol Cell. 2000 Mar;11(3):819-31. PubMed PMID: 10712502; PubMed Central PMCID: PMC14813.

Lavelle JP, Meyers SA, Ruiz WG, Buffington CA, Zeidel ML, Apodaca G. Urothelial pathophysiological changes in feline interstitial cystitis: a human model. Am J Physiol Renal Physiol. 2000 Apr;278(4):F540-53. PubMed PMID: 10751214.

Leung SM, Ruiz WG, Apodaca G. Sorting of membrane and fluid at the apical pole of polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2000 Jun;11(6):2131-50. PubMed PMID: 10848634; PubMed Central PMCID: PMC14908.

Liu SH, Towler MC, Chen E, Chen CY, Song W, Apodaca G, Brodsky FM. A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network. EMBO J. 2001 Jan 15;20(1-2):272-84. PubMed PMID: 11226177; PubMed Central PMCID: PMC140205.

Rojas R, Ruiz WG, Leung SM, Jou TS, Apodaca G. Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2001 Aug;12(8):2257-74. PubMed PMID: 11514615; PubMed Central PMCID: PMC58593.

Rajasekaran SA, Palmer LG, Moon SY, Peralta Soler A, Apodaca GL, Harper JF, Zheng Y, Rajasekaran AK. Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells. Mol Biol Cell. 2001 Dec;12(12):3717-32. PubMed PMID: 11739775; PubMed Central PMCID: PMC60750.

Truschel ST, Wang E, Ruiz WG, Leung SM, Rojas R, Lavelle J, Zeidel M, Stoffer D, Apodaca G. Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. Mol Biol Cell. 2002 Mar;13(3):830-46. PubMed PMID: 11907265; PubMed Central PMCID: PMC99602.

Magyar CE, White KE, Rojas R, Apodaca G, Friedman PA. Plasma membrane Ca2+-ATPase and NCX1 Na+/Ca2+ exchanger expression in distal convoluted tubule cells. Am J Physiol Renal Physiol. 2002 Jul;283(1):F29-40. PubMed PMID: 12060584.

Lavelle J, Meyers S, Ramage R, Bastacky S, Doty D, Apodaca G, Zeidel ML. Bladder permeability barrier: recovery from selective injury of surface epithelial cells. Am J Physiol Renal Physiol. 2002 Aug;283(2):F242-53. PubMed PMID: 12110507.

Birder LA, Nealen ML, Kiss S, de Groat WC, Caterina MJ, Wang E, Apodaca G, Kanai AJ. Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. J Neurosci. 2002 Sep 15;22(18):8063-70. PubMed PMID: 12223560.

Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, Wang E, Ruiz G, De Groat WC, Apodaca G, Watkins S, Caterina MJ. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci. 2002 Sep;5(9):856-60. PubMed PMID: 12161756.

Kanai AJ, Zeidel ML, Lavelle JP, Greenberger JS, Birder LA, de Groat WC, Apodaca GL, Meyers SA, Ramage R, Epperly MW. Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis. Am J Physiol Renal Physiol. 2002 Dec;283(6):F1304-12. PubMed PMID: 12426235.

Apodaca G, Kiss S, Ruiz W, Meyers S, Zeidel M, Birder L. Disruption of bladder epithelium barrier function after spinal cord injury. Am J Physiol Renal Physiol. 2003 May;284(5):F966-76. Epub 2003 Jan 14. PubMed PMID: 12527557.

Wang E, Truschel S, Apodaca G. Analysis of hydrostatic pressure-induced changes in umbrella cell surface area. Methods. 2003 Jul;30(3):207-17. PubMed PMID: 12798135.

Wang EC, Lee JM, Johnson JP, Kleyman TR, Bridges R, Apodaca G. Hydrostatic pressure-regulated ion transport in bladder uroepithelium. Am J Physiol Renal Physiol. 2003 Oct;285(4):F651-63. Epub 2003 May 27. PubMed PMID: 12770841.

Kanai A, Epperly M, Pearce L, Birder L, Zeidel M, Meyers S, Greenberger J, de Groat W, Apodaca G, Peterson J. Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells. Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H13-21. Erratum in: Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H536. PubMed PMID: 14684357.

Pollack AL, Apodaca G, Mostov KE. Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity. Am J Physiol Cell Physiol. 2004 Mar;286(3):C482-94. Epub 2003 Oct 30. PubMed PMID: 14592813.

Cetin S, Ford HR, Sysko LR, Agarwal C, Wang J, Neal MD, Baty C, Apodaca G, Hackam DJ. Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions. J Biol Chem. 2004 Jun 4;279(23):24592-600. Epub 2004 Mar 30. PubMed PMID: 15169791.

Hill WG, Mathai JC, Gensure RH, Zeidel JD, Apodaca G, Saenz JP, Kinne-Saffran E, Kinne R, Zeidel ML. Permeabilities of teleost and elasmobranch gill apical membranes: evidence that lipid bilayers alone do not account for barrier function. Am J Physiol Cell Physiol. 2004 Jul;287(1):C235-42. Epub 2004 Mar 3. PubMed PMID: 14998788.

Acharya P, Beckel J, Ruiz WG, Wang E, Rojas R, Birder L, Apodaca G. Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. Am J Physiol Renal Physiol. 2004 Aug;287(2):F305-18. Epub 2004 Apr 6. PubMed PMID: 15068973.

Zeidel JD, Mathai JC, Campbell JD, Ruiz WG, Apodaca GL, Riordan J, Zeidel ML. Selective permeability barrier to urea in shark rectal gland. Am J Physiol Renal Physiol. 2005 Jul;289(1):F83-9. Epub 2005 Feb 22. PubMed PMID: 15727989.

Hill WG, Southern NM, MacIver B, Potter E, Apodaca G, Smith CP, Zeidel ML. Isolation and characterization of the Xenopus oocyte plasma membrane: a new method for studying activity of water and solute transporters. Am J Physiol Renal Physiol. 2005 Jul;289(1):F217-24. Epub 2005 Mar 1. PubMed PMID: 15741609.

Hill WG, Almasri E, Ruiz WG, Apodaca G, Zeidel ML. Water and solute permeability of rat lung caveolae: high permeabilities explained by acyl chain unsaturation. Am J Physiol Cell Physiol. 2005 Jul;289(1):C33-41. Epub 2005 Feb 23. PubMed PMID: 15728712.

Wang EC, Lee JM, Ruiz WG, Balestreire EM, von Bodungen M, Barrick S, Cockayne DA, Birder LA, Apodaca G. ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J Clin Invest. 2005 Sep;115(9):2412-22. Epub 2005 Aug 18. PubMed PMID: 16110327; PubMed Central PMCID: PMC1187935.

Ducharme NA, Hales CM, Lapierre LA, Ham AJ, Oztan A, Apodaca G, Goldenring JR. MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. Mol Biol Cell. 2006 Aug;17(8):3625-37. Epub 2006 Jun 14. PubMed PMID: 16775013; PubMed Central PMCID: PMC1525241.

Yu W, Zacharia LC, Jackson EK, Apodaca G. Adenosine receptor expression and function in bladder uroepithelium. Am J Physiol Cell Physiol. 2006 Aug;291(2):C254-65. Epub 2006 Mar 29. PubMed PMID: 16571869.

Morimoto T, Liu W, Woda C, Carattino MD, Wei Y, Hughey RP, Apodaca G, Satlin LM, Kleyman TR. Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct. Am J Physiol Renal Physiol. 2006 Sep;291(3):F663-9. Epub 2006 Apr 25. PubMed PMID: 16638910.

Balestreire EM, Apodaca G. Apical epidermal growth factor receptor signaling: regulation of stretch-dependent exocytosis in bladder umbrella cells. Mol Biol Cell. 2007 Apr;18(4):1312-23. Epub 2007 Feb 7. PubMed PMID: 17287395; PubMed Central PMCID: PMC1838979.

Rondanino C, Rojas R, Ruiz WG, Wang E, Hughey RP, Dunn KW, Apodaca G. RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. Traffic. 2007 Jul;8(7):932-49. Epub 2007 Jun 4. PubMed PMID: 17547697.

Ameen N, Apodaca G. Defective CFTR apical endocytosis and enterocyte brush border in myosin VI-deficient mice. Traffic. 2007 Aug;8(8):998-1006. Epub 2007 Jun 6. PubMed PMID: 17555536.

Cresawn KO, Potter BA, Oztan A, Guerriero CJ, Ihrke G, Goldenring JR, Apodaca G, Weisz OA. Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins. EMBO J. 2007 Aug 22;26(16):3737-48. Epub 2007 Aug 2. PubMed PMID: 17673908; PubMed Central PMCID: PMC1952228.

Ducharme NA, Williams JA, Oztan A, Apodaca G, Lapierre LA, Goldenring JR. Rab11-FIP2 regulates differentiable steps in transcytosis. Am J Physiol Cell Physiol. 2007 Sep;293(3):C1059-72. Epub 2007 Jul 11. PubMed PMID: 17626244.

Oztan A, Silvis M, Weisz OA, Bradbury NA, Hsu SC, Goldenring JR, Yeaman C, Apodaca G. Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell. 2007 Oct;18(10):3978-92. Epub 2007 Aug 8. PubMed PMID: 17686995; PubMed Central PMCID: PMC1995710.

Hill WG, Meyers S, von Bodungen M, Apodaca G, Dedman JR, Kaetzel MA, Zeidel ML. Studies on localization and function of annexin A4a within urinary bladder epithelium using a mouse knockout model. Am J Physiol Renal Physiol. 2008 Apr;294(4):F919-27. Epub 2008 Feb 6. PubMed PMID: 18256316; PubMed Central PMCID: PMC2603049.

Khandelwal P, Ruiz WG, Balestreire-Hawryluk E, Weisz OA, Goldenring JR, Apodaca G. Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15773-8. Epub 2008 Oct 8. PubMed PMID: 18843107; PubMed Central PMCID: PMC2572972.

Studeny S, Cheppudira BP, Meyers S, Balestreire EM, Apodaca G, Birder LA, Braas KM, Waschek JA, May V, Vizzard MA. Urinary bladder function and somatic sensitivity in vasoactive intestinal polypeptide (VIP)-/- mice. J Mol Neurosci. 2008 Nov;36(1-3):175-87. Epub 2008 Jun 17. PubMed PMID: 18561033; PubMed Central PMCID: PMC2693375.

Yu W, Khandelwal P, Apodaca G. Distinct apical and basolateral membrane requirements for stretch-induced membrane traffic at the apical surface of bladder umbrella cells. Mol Biol Cell. 2009 Jan;20(1):282-95. Epub 2008 Nov 5. PubMed PMID: 18987341; PubMed Central PMCID: PMC2613117.

Khandelwal P, Ruiz WG, Apodaca G. Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway. EMBO J. 2010 Jun 16;29(12):1961-75. Epub 2010 May 11. PubMed PMID:20461056.

Yu W, Hill WG, Apodaca G, Zeidel ML. Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am J Physiol Renal Physiol. 2011 Jan;300(1):F49-59. Epub 2010 Oct 13. PubMed PMID: 20943764; PubMed Central PMCID: PMC3023226.

Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep;301(3):F622-33. Epub 2011 Jun 15. PubMed PMID: 21677144; PubMed Central PMCID: PMC3174547.

Butterworth MB, Edinger RS, Silvis MR, Gallo LI, Liang X, Apodaca G, Fizzell RA, Johnson JP. Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC). Am J Physiol Renal Physiol. 2012 Mar;302(5):F581-90. doi: 10.​1152/​ajprenal.​00304.​2011. Epub 2011 Nov 30. PubMed PMID: 22129970; PubMed Central PMCID: PMC3353647.

Lapierre LA, Avant KM, Caldwell CM, Oztan A, Apodaca G, Knowles BC, Roland JT, Ducharme NA, Goldenring JR. Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Mol Biol Cell. 2012 Jun;23(12):2302-2318. Epub 2012 May 2. PubMed PMID: 22553350; PubMed Central PMCID: PMC3374749..

Prakasam HS, Herrington H, Roppolo JR, Jackson EK, Apodaca G. Modulation of bladder function by luminal adenosine turnover and A1 receptor activation. Am J Physiol Renal Physiol. 2012 Jul 15;303(2):F279-92. Epub 2012 May 2. PubMed PMID: 22552934; PubMed Central PMCID: PMC3404591.

Lapierre LA, Avant KM, Caldwell CM, Oztan A, Apodaca G, Knowles BC, Roland JT, Ducharme NA, Goldenring JR. Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Mol Biol Cell. 2012 Jun;23(12):2302-18. Epub 2012 May 2. PubMed PMID: 22553350; PubMed Central PMCID: PMC3374749.

Mitra S, Lukianov S, Ruiz WG, Cianciolo Cosentino C, Sanker S, Traub LM, Hukriede NA, Apodaca G. Requirement for a uroplakin 3a-like protein in the development of zebrafish pronephric tubule epithelial cell function, morphogenesis, and polarity. PLoS One. 2012;7(7):e41816. Epub 2012 Jul 25. PubMed PMID: 22848617; PubMed Central PMCID: PMC3404999.

Edinger RS, Bertrand CA, Rondandino C, Apodaca G, Johnson JP, Butterworth MB. The Epithelial Sodium Channel (ENaC) Establishes a Trafficking Vesicle Pool Responsible for Its Regulation. PLoS One. 2012;7(9):e46593. doi: 10.1371/journal.pone.0046593. Epub 2012 Sep 28. PubMed PMID: 23029554; PubMed Central PMCID: PMC3460899.

Hanna-Mitchell AT, Ruiz GW, Daneshgari F, Liu G, Apodaca G, Birder LA. Impact of diabetes mellitus on bladder uroepithelial cells. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R84-93. doi: 10.1152/ajpregu.00129.2012. Epub 2012 Nov 21. PubMed PMID: 23174855; PubMed Central PMCID: PMC3543662.

Szalinski CM, Guerriero CJ, Ruiz WG, Docter BE, Rbaibi Y, Pastor-Soler NM, Apodaca G, Puthenveedu MA, Weisz OA. PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells. PLoS One. 2013;8(1):e53790. PubMed PMID: 23342003; PubMedCentral PMCID: PMC3547069.

Khandelwal P, Prakasam HS, Clayton DR, Ruiz WG, Gallo LI, van Roekel D, Lukianov S, Peränen J, Goldenring JR, Apodaca G. A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells. Mol Biol Cell. 2013 Apr;24(7):1007-19. Epub 2013 Feb 6. PubMed Central PMCID: PMC3608489.

Carattino MD, Prakasam HS, Ruiz WG, Clayton DR, McGuire M, Gallo LI, Apodaca G. Bladder filling and voiding affect umbrella cell tight junction organization and function. Am J Physiol Renal Physiol. 2013 Oct;305(8):F1158-F1168. Epub 2013 Jul 24. PubMed PMID: 23884145.

Chakraborty S, Umasankar PK, Preston GM, Khandelwal P, Apodaca G, Watkins SC, Traub LM. A phosphotyrosine switch for cargo sequestration at clathrin-coated buds. J Biol Chem. 2014 Jun 20;289(25):17497-514. doi: 10.1074/jbc.M114.556589. Epub 2014 May 5. PubMed PMID: 24798335; PubMed Central PMCID: PMC4067187.

Gallo LI, Liao Y, Ruiz WG, Clayton DR, Li M, Liu YJ, Jiang Y, Fukuda M, Apodaca G, Yin XM. TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Mol Biol Cell. 2014 Nov 15;25(23):3779-97. doi: 10.1091/mbc.E13-10-0604. Epub 2014 Sep 17. PubMed PMID: 25232007; PubMed Central PMCID: PMC4230784.

Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15;25(23):3798-812. doi: 10.1091/mbc.E14-03-0818. Epub 2014 Sep 17. PubMed PMID: 25232008; PubMed Central PMCID: PMC4230785.

Montalbetti N, Rued AC, Clayton DR, Ruiz WG, Bastacky SI, Prakasam HS, Eaton AF, Kullmann FA, Apodaca G, Carattino MD. Increased urothelial paracellular transport promotes cystitis. Am J Physiol Renal Physiol. 2015 Dec 15;309(12):F1070-81. doi: 10.1152/ajprenal.00200.2015. Epub 2015 Sep 30. PubMed PMID: 26423859; PubMed Central PMCID: PMC4683306.

Sneddon WB, Ruiz GW, Gallo LI, Xiao K, Zhang Q, Rbaibi Y, Weisz OA, Apodaca GL, Friedman PA. Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport. J Biol Chem. 2016 Jul 18. pii: jbc.M116.744052. [Epub ahead of print] PubMed PMID: 27432882.

Moulton DE, Sulzer V, Apodaca G, Byrne HM, Waters S. Mathematical modeling of stretch-induced traffic in bladder umbrella cells. J Theor Biol. 2016. Nov 21;409:115-132. doi: 10.1016/j.jtbi.2016.08.032. PubMed PMID: 27590325.

Enter the name for this tabbed section: Review Articles
Rutka JT, Apodaca G, Stern R, Rosenblum M. The extracellular matrix of the central and peripheral nervous systems: structure and function. J Neurosurg. 1988 Aug;69(2):155-70. Review. PubMed PMID: 3292716.

Apodaca G, Bomsel M, Arden J, Breitfeld PP, Tang K, Mostov KE. The polymeric immunoglobulin receptor. A model protein to study transcytosis. J Clin Invest. 1991 Jun;87(6):1877-82. Review. PubMed PMID: 2040683; PubMed Central PMCID: PMC296937.

Mostov K, Apodaca G, Aroeti B, Okamoto C. Plasma membrane protein sorting in polarized epithelial cells. J Cell Biol. 1992 Feb;116(3):577-83. Review. PubMed PMID: 1730769; PubMed Central PMCID: PMC2289323.

Apodaca G. Endocytic traffic in polarized epithelial cells: role of the actin and microtubule cytoskeleton. Traffic. 2001 Mar;2(3):149-59. Review. PubMed PMID: 11260520.

Apodaca G. Modulation of membrane traffic by mechanical stimuli. Am J Physiol Renal Physiol. 2002 Feb;282(2):F179-90. Review. PubMed PMID: 11788431.

Rojas R, Apodaca G. Immunoglobulin transport across polarized epithelial cells. Nat Rev Mol Cell Biol. 2002 Dec;3(12):944-55. Review. PubMed PMID: 12461560.

Traub LM, Apodaca G. AP-1B: polarized sorting at the endosome. Nat Cell Biol. 2003 Dec;5(12):1045-7. PubMed PMID: 14647300.

Apodaca G. The uroepithelium: not just a passive barrier. Traffic. 2004 Mar;5(3):117-28. Review. PubMed PMID: 15086788.

Apodaca G. Synaptotagmins: mediators of Ca2+-regulated vesicle fusion. Focus on "stable gene silencing of synaptotagmin I in rat PC12 cells inhibits Ca2+-evoked release of catecholamine". Am J Physiol Cell Physiol. 2006 Aug;291(2):C234-6. Epub 2006 May 31. PubMed PMID: 16738005.

Apodaca G, Balestreire E, Birder LA. The uroepithelial-associated sensory web. Kidney Int. 2007 Nov;72(9):1057-64. Epub 2007 Aug 1. Review. PubMed PMID: 17667988.

Oztan A, Rondanino C, Apodaca G. Transcytosis of polymeric immunoglobulin a in polarized Madin-Darby canine kidney cells. Methods Mol Biol. 2008;440:157-70. PubMed PMID: 18369944; PubMed Central PMCID: PMC2603048.

Khandelwal P, Abraham SN, Apodaca G. Cell biology and physiology of the uroepithelium. Am J Physiol Renal Physiol. 2009 Dec;297(6):F1477 501. Epub 2009 Jul 8. Review. PubMed PMID: 19587142; PubMed Central PMCID: PMC2801337

Apodaca G. Opening ahead: early steps in lumen formation revealed. Nat Cell Biol. 2010 Nov;12(11):1026-8. PubMed PMID: 21045801.

Apodaca G, Gallo LI, Bryant DM. Role of membrane traffic in the generation of epithelial cell asymmetry. Nat Cell Biol. 2012 Dec;14(12):1235-43. PubMed PMID: 23196841.

Apodaca G, Brown WJ. Membrane traffic research: challenges for the next decade. Front Cell Dev Biol. 2014 Sep 17;2:52. doi: 10.3389/fcell.2014.00052. eCollection 2014. PubMed PMID: 25364759; PubMed Central PMCID: PMC4207031.

Apodaca, G. Role of polarity proteins in the generation and organization of apical protrusions. Cold Spring Harbor Perspectives. 2016. (in press)

Enter the name for this tabbed section: Books and Chapters
Birder, LA, DeGroat, WC, Apodaca, G. Physiology of the urothelium. In Textbook of the Neurogenic Bladder, 2nd edition, J. Corcos and E. Schick, Eds. Informa Healthcare, London, G.B. 2008, pp 19-39.

Apodaca G, Gallo LI. Epithelial Polarity. In: Colloquium series on building blocks of the cell: cell structure and function. Nabi RI editor. Morgan and Claypool Life Sciences, 2013.