Department of Medicine
Contact Information:
University of Pittsburgh
Renal/Electrolyte Division
982 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Telephone: 412-648-9105
Fax: 412-383-8955/8956
E-mail: ruizw@pitt.edu
Education and Training:
Undergraduate:
Instituto Technico Agricultura, Barcenas Villa Nueva, Guatemala, 1974-1979
Publications :
1. Maples, C., Ruiz, W.G. and Apodaca, G. Both actin and microtubules are required for efficient postendocytic traffic in MDCK cells. Journal of Biological Chemistry. 272:6741-6751, 1997. (click here to download this article in PDF format)
2. Lavelle, J.P., Apodaca, G., Meyers, S.A., Ruiz, W.G. and Zeidel, M.L. Disruption of the guinea pig urinary bladder permeability barrier in noninfectious cystitis. American Journal of Physiology. 274:F205-214, 1998. (click here to download this article in PDF format)
3. Truschel, S.T., Ruiz, W.G., Shulman, T.S., Pilewski, J.M., Sun, T.-T., Zeidel, M.L. and Apodaca, G. Primary uroepithelial cultures: a model system to analyze umbrella cell barrier function. Journal of Biological Chemistry. 274:15020-15029, 1999. (click here to download this article in PDF format)
4. Leung, S.-M., Rojas, R., Maples, C., Flynn, C., Ruiz, W.G., Jou, T.-S. and Apodaca, G. Modulation of endocytic traffic in polarized MDCK cells by the small GTPase RhoA. Molecular Biology of the Cell. 10:4369-4384, 1999. (click here to download this article in PDF format)
5. Jou, T.-S., Leung, S.-M., Fung, L., Ruiz W., Nelson, J. and Apodaca, G. Selective alterations in biosynthetic and endocytic protein traffic in MDCK epithelial cells expressing mutants of the small GTPase Rac1. Molecular Biology of the Cell. 11:287-304, 2000. (click here to download this article in PDF format)
6. Lavelle, J.P., Meyers, S.A., Ruiz, W.G., Buffington, C.A.T., Zeidel, M.L. and Apodaca, G. Functional and structural urothelial derangements in feline interstitial cystitis: a human interstitial cystitis model. American Journal of Physiology. 278:F540-F553, 2000. (click here to download this article in PDF format)
7. Leung, S.-M., Ruiz, W.G. and Apodaca, G. Sorting of membrane and fluid at the apical pole of polarized MDCK cells. Molecular Biology of the Cell. 11:2131-2150, 2000. (click here to download this article in PDF format)
8. Rojas, R., W.G. Ruiz, S.-M. Leung, T.-S. Jou, and G. Apodaca. Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized MDCK epithelial cells. Molecular Biology of the Cell. 12:2257-2274, 2001. (click here to download this article in PDF format)
9. Truschel, S., Wang, E., Ruiz, W.G., Leung, S.-M., Rojas, R., Lavelle, J., Zeidel, M., Stoffer, D., and Apodaca, G. Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. Molecular Biology of the Cell. 13:830-846, 2002. (click here to download this article in PDF format)
10. Birder, L.A., Nakamura, Y., Kiss, S., Nealan, M.L., Barrick, S., Kanai, A.J., Wang, E., Ruiz, G., deGroat, W.C., Apodaca, G., Watkins, S., and Caterina, J. Altered bladder function in mice lacking the vanilloid receptor TRPV1. Nature Neuroscience, 5:856-860. 2002. (click here to download this article in PDF format)
11. Apodaca, G., Kiss, S., Ruiz, W., Meyers, S., Zeidel, M., and Birder, L. Disruption of bladder epithelium barrier function after spinal cord injury. American Journal of Physiology. 284:F966-F976, 2003. (click here to download this article in PDF format)
12. Archaya, P., Beckel, J., Wang, E., Ruiz, W.G., Rojas, R., and Apodaca G. Distribution of the tight junction proteins ZO-1, occludin and claudin-4, -8, and -12 in bladder epithelium. American Journal of Physiology. 287:F305-F318, 2004. (click here to download this article in PDF format)
13. Hill, W.G., Almasri, E., Ruiz, W.G., Apodaca, G., Zeidel, M.L. Water and solute permeability of rat lung caveolae: High permeabilities explained by acyl chain unsaturation. American Journal of Physiology. 289:C33-41, 2005. (click here to download this article in PDF format)
14. Zeidel, J.D., Mathai, J.C., Campbell, J.D., Ruiz, W.G., Apodaca, G., Riordan, J., Zeidel. M.L. Selective Permeability Barrier to Urea in Shark Rectal Gland. American Journal of Physiology. 289:F83-89, 2005. (click here to download this article in PDF format)
15. Wang, E.C., Lee, J.-M., Ruiz, W.G., Balestreire, E., von Bodungen, M., Barrick, S., Cockayne, D., Birder, L., and Apodaca, G. ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. Journal of Clinical Investigation. 115:2412-2422, 2005. (click here to download this article in PDF format)
16. Rondanino, C., Rojas, R., Ruiz, W.G., Wang, E., Hughey, R.P., Dunn, K.W., and Apodaca, G. RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby Canine kidney cells. Traffic. 8:932-949, 2007. (click here to download this article in PDF format)
17. Khandelwal, P., Ruiz, W.G., Balestreire-Hawrluk, E., Weisz, O.A., Goldenring, J.R., and Apodaca, G. Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proceedings of the National Academy of Sciences USA. 105:15773-15778, 2008. (click here to download this article in PDF format)
