Apodaca Lab Publications

Publications (in chronological order):

Maples CJ, Ruiz WG, Apodaca G. Both microtubules and actin filaments are required for efficient postendocytotic traffic of the polymeric immunoglobulin receptor in polarized Madin-Darby canine kidney cells. J Biol Chem. 1997 Mar 7;272(10):6741-51. PubMed PMID: 9045707.

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Kang PJ, Hauser AR, Apodaca G, Fleiszig SM, Wiener-Kronish J, Mostov K, Engel JN. Identification of Pseudomonas aeruginosa genes required for epithelial cell injury. Mol Microbiol. 1997 Jun;24(6):1249-62. PubMed PMID: 9218773.

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Lavelle JP, Apodaca G, Meyers SA, Ruiz WG, Zeidel ML. Disruption of guinea pig urinary bladder permeability barrier in noninfectious cystitis. Am J Physiol. 1998 Jan;274(1 Pt 2):F205-14. PubMed PMID: 9458841.

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Leung SM, Chen D, DasGupta BR, Whiteheart SW, Apodaca G. SNAP-23 requirement for transferrin recycling in Streptolysin-O-permeabilized Madin-Darby canine kidney cells. J Biol Chem. 1998 Jul 10;273(28):17732-41. PubMed PMID: 9651373.

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Birder LA, Apodaca G, De Groat WC, Kanai AJ. Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. Am J Physiol. 1998 Aug;275(2 Pt 2):F226-9. PubMed PMID: 9691011.

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Henkel JR, Apodaca G, Altschuler Y, Hardy S, Weisz OA. Selective perturbation of apical membrane traffic by expression of influenza M2, an acid-activated ion channel, in polarized madin-darby canine kidney cells. Mol Biol Cell. 1998 Sep;9(9):2477-90. PubMed PMID: 9725907; PubMed Central PMCID: PMC25516.

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Truschel ST, Ruiz WG, Shulman T, Pilewski J, Sun TT, Zeidel ML, Apodaca G. Primary uroepithelial cultures. A model system to analyze umbrella cell barrier function. J Biol Chem. 1999 May 21;274(21):15020-9. Review. PubMed PMID:10329705.

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Altschuler Y, Liu S, Katz L, Tang K, Hardy S, Brodsky F, Apodaca G, Mostov K. ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells. J Cell Biol. 1999 Oct 4;147(1):7-12. PubMed PMID: 10508850; PubMed Central PMCID: PMC2164974.

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Leung SM, Rojas R, Maples C, Flynn C, Ruiz WG, Jou TS, Apodaca G. Modulation of endocytic traffic in polarized Madin-Darby canine kidney cells by the small GTPase RhoA. Mol Biol Cell. 1999 Dec;10(12):4369-84. PubMed PMID: 10588664; PubMed Central PMCID: PMC25764.

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Jou TS, Leung SM, Fung LM, Ruiz WG, Nelson WJ, Apodaca G. Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1. Mol Biol Cell. 2000 Jan;11(1):287-304. PubMed PMID: 10637309; PubMed Central PMCID: PMC14775.

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Altschuler Y, Kinlough CL, Poland PA, Bruns JB, Apodaca G, Weisz OA, Hughey RP. Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation state. Mol Biol Cell. 2000 Mar;11(3):819-31. PubMed PMID: 10712502; PubMed Central PMCID: PMC14813.

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Lavelle JP, Meyers SA, Ruiz WG, Buffington CA, Zeidel ML, Apodaca G. Urothelial pathophysiological changes in feline interstitial cystitis: a human model. Am J Physiol Renal Physiol. 2000 Apr;278(4):F540-53. PubMed PMID: 10751214.

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Leung SM, Ruiz WG, Apodaca G. Sorting of membrane and fluid at the apical pole of polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2000 Jun;11(6):2131-50. PubMed PMID: 10848634; PubMed Central PMCID: PMC14908.

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Liu SH, Towler MC, Chen E, Chen CY, Song W, Apodaca G, Brodsky FM. A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network. EMBO J. 2001 Jan 15;20(1-2):272-84. PubMed PMID: 11226177; PubMed Central PMCID: PMC140205.

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Rojas R, Ruiz WG, Leung SM, Jou TS, Apodaca G. Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2001 Aug;12(8):2257-74. PubMed PMID: 11514615; PubMed Central PMCID: PMC58593.

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Rajasekaran SA, Palmer LG, Moon SY, Peralta Soler A, Apodaca GL, Harper JF, Zheng Y, Rajasekaran AK. Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells. Mol Biol Cell. 2001 Dec;12(12):3717-32. PubMed PMID: 11739775; PubMed Central PMCID: PMC60750.

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Truschel ST, Wang E, Ruiz WG, Leung SM, Rojas R, Lavelle J, Zeidel M, Stoffer D, Apodaca G. Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. Mol Biol Cell. 2002 Mar;13(3):830-46. PubMed PMID: 11907265; PubMed Central PMCID: PMC99602.

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Magyar CE, White KE, Rojas R, Apodaca G, Friedman PA. Plasma membrane Ca2+-ATPase and NCX1 Na+/Ca2+ exchanger expression in distal convoluted tubule cells. Am J Physiol Renal Physiol. 2002 Jul;283(1):F29-40. PubMed PMID: 12060584.

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Lavelle J, Meyers S, Ramage R, Bastacky S, Doty D, Apodaca G, Zeidel ML. Bladder permeability barrier: recovery from selective injury of surface epithelial cells. Am J Physiol Renal Physiol. 2002 Aug;283(2):F242-53. PubMed PMID: 12110507.

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Birder LA, Nealen ML, Kiss S, de Groat WC, Caterina MJ, Wang E, Apodaca G, Kanai AJ. Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. J Neurosci. 2002 Sep 15;22(18):8063-70. PubMed PMID: 12223560.

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Kanai AJ, Zeidel ML, Lavelle JP, Greenberger JS, Birder LA, de Groat WC, Apodaca GL, Meyers SA, Ramage R, Epperly MW. Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis. Am J Physiol Renal Physiol. 2002 Dec;283(6):F1304-12. PubMed PMID: 12426235.

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Apodaca G, Kiss S, Ruiz W, Meyers S, Zeidel M, Birder L. Disruption of bladder epithelium barrier function after spinal cord injury. Am J Physiol Renal Physiol. 2003 May;284(5):F966-76. Epub 2003 Jan 14. PubMed PMID: 12527557.

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Wang E, Truschel S, Apodaca G. Analysis of hydrostatic pressure-induced changes in umbrella cell surface area. Methods. 2003 Jul;30(3):207-17. PubMed PMID: 12798135.

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Wang EC, Lee JM, Johnson JP, Kleyman TR, Bridges R, Apodaca G. Hydrostatic pressure-regulated ion transport in bladder uroepithelium. Am J Physiol Renal Physiol. 2003 Oct;285(4):F651-63. Epub 2003 May 27. PubMed PMID: 12770841.

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Kanai A, Epperly M, Pearce L, Birder L, Zeidel M, Meyers S, Greenberger J, de Groat W, Apodaca G, Peterson J. Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells. Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H13-21. Erratum in: Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H536. PubMed PMID: 14684357.

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Pollack AL, Apodaca G, Mostov KE. Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity. Am J Physiol Cell Physiol. 2004 Mar;286(3):C482-94. Epub 2003 Oct 30. PubMed PMID: 14592813.

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Cetin S, Ford HR, Sysko LR, Agarwal C, Wang J, Neal MD, Baty C, Apodaca G, Hackam DJ. Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions. J Biol Chem. 2004 Jun 4;279(23):24592-600. Epub 2004 Mar 30. PubMed PMID: 15169791.

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Hill WG, Mathai JC, Gensure RH, Zeidel JD, Apodaca G, Saenz JP, Kinne-Saffran E, Kinne R, Zeidel ML. Permeabilities of teleost and elasmobranch gill apical membranes: evidence that lipid bilayers alone do not account for barrier function. Am J Physiol Cell Physiol. 2004 Jul;287(1):C235-42. Epub 2004 Mar 3. PubMed PMID: 14998788.

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Acharya P, Beckel J, Ruiz WG, Wang E, Rojas R, Birder L, Apodaca G. Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. Am J Physiol Renal Physiol. 2004 Aug;287(2):F305-18. Epub 2004 Apr 6. PubMed PMID: 15068973.

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Zeidel JD, Mathai JC, Campbell JD, Ruiz WG, Apodaca GL, Riordan J, Zeidel ML. Selective permeability barrier to urea in shark rectal gland. Am J Physiol Renal Physiol. 2005 Jul;289(1):F83-9. Epub 2005 Feb 22. PubMed PMID: 15727989.

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Hill WG, Southern NM, MacIver B, Potter E, Apodaca G, Smith CP, Zeidel ML. Isolation and characterization of the Xenopus oocyte plasma membrane: a new method for studying activity of water and solute transporters. Am J Physiol Renal Physiol. 2005 Jul;289(1):F217-24. Epub 2005 Mar 1. PubMed PMID: 15741609.

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Hill WG, Almasri E, Ruiz WG, Apodaca G, Zeidel ML. Water and solute permeability of rat lung caveolae: high permeabilities explained by acyl chain unsaturation. Am J Physiol Cell Physiol. 2005 Jul;289(1):C33-41. Epub 2005 Feb 23. PubMed PMID: 15728712.

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Wang EC, Lee JM, Ruiz WG, Balestreire EM, von Bodungen M, Barrick S, Cockayne DA, Birder LA, Apodaca G. ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J Clin Invest. 2005 Sep;115(9):2412-22. Epub 2005 Aug 18. PubMed PMID: 16110327; PubMed Central PMCID: PMC1187935.

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Ducharme NA, Hales CM, Lapierre LA, Ham AJ, Oztan A, Apodaca G, Goldenring JR. MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. Mol Biol Cell. 2006 Aug;17(8):3625-37. Epub 2006 Jun 14. PubMed PMID: 16775013; PubMed Central PMCID: PMC1525241.

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Yu W, Zacharia LC, Jackson EK, Apodaca G. Adenosine receptor expression and function in bladder uroepithelium. Am J Physiol Cell Physiol. 2006 Aug;291(2):C254-65. Epub 2006 Mar 29. PubMed PMID: 16571869.

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Morimoto T, Liu W, Woda C, Carattino MD, Wei Y, Hughey RP, Apodaca G, Satlin LM, Kleyman TR. Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct. Am J Physiol Renal Physiol. 2006 Sep;291(3):F663-9. Epub 2006 Apr 25. PubMed PMID: 16638910.

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Balestreire EM, Apodaca G. Apical epidermal growth factor receptor signaling: regulation of stretch-dependent exocytosis in bladder umbrella cells. Mol Biol Cell. 2007 Apr;18(4):1312-23. Epub 2007 Feb 7. PubMed PMID: 17287395; PubMed Central PMCID: PMC1838979.

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Rondanino C, Rojas R, Ruiz WG, Wang E, Hughey RP, Dunn KW, Apodaca G. RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. Traffic. 2007 Jul;8(7):932-49. Epub 2007 Jun 4. PubMed PMID: 17547697.

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Ameen N, Apodaca G. Defective CFTR apical endocytosis and enterocyte brush border in myosin VI-deficient mice. Traffic. 2007 Aug;8(8):998-1006. Epub 2007 Jun 6. PubMed PMID: 17555536.

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Cresawn KO, Potter BA, Oztan A, Guerriero CJ, Ihrke G, Goldenring JR, Apodaca G, Weisz OA. Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins. EMBO J. 2007 Aug 22;26(16):3737-48. Epub 2007 Aug 2. PubMed PMID: 17673908; PubMed Central PMCID: PMC1952228.

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Ducharme NA, Williams JA, Oztan A, Apodaca G, Lapierre LA, Goldenring JR. Rab11-FIP2 regulates differentiable steps in transcytosis. Am J Physiol Cell Physiol. 2007 Sep;293(3):C1059-72. Epub 2007 Jul 11. PubMed PMID: 17626244.

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Oztan A, Silvis M, Weisz OA, Bradbury NA, Hsu SC, Goldenring JR, Yeaman C, Apodaca G. Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell. 2007 Oct;18(10):3978-92. Epub 2007 Aug 8. PubMed PMID: 17686995; PubMed Central PMCID: PMC1995710.

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Hill WG, Meyers S, von Bodungen M, Apodaca G, Dedman JR, Kaetzel MA, Zeidel ML. Studies on localization and function of annexin A4a within urinary bladder epithelium using a mouse knockout model. Am J Physiol Renal Physiol. 2008 Apr;294(4):F919-27. Epub 2008 Feb 6. PubMed PMID: 18256316; PubMed Central PMCID: PMC2603049.

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Khandelwal P, Ruiz WG, Balestreire-Hawryluk E, Weisz OA, Goldenring JR, Apodaca G. Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15773-8. Epub 2008 Oct 8. PubMed PMID: 18843107; PubMed Central PMCID: PMC2572972.

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Studeny S, Cheppudira BP, Meyers S, Balestreire EM, Apodaca G, Birder LA, Braas KM, Waschek JA, May V, Vizzard MA. Urinary bladder function and somatic sensitivity in vasoactive intestinal polypeptide (VIP)-/- mice. J Mol Neurosci. 2008 Nov;36(1-3):175-87. Epub 2008 Jun 17. PubMed PMID: 18561033; PubMed Central PMCID: PMC2693375.

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Yu W, Khandelwal P, Apodaca G. Distinct apical and basolateral membrane requirements for stretch-induced membrane traffic at the apical surface of bladder umbrella cells. Mol Biol Cell. 2009 Jan;20(1):282-95. Epub 2008 Nov 5. PubMed PMID: 18987341; PubMed Central PMCID: PMC2613117.

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Khandelwal P, Ruiz WG, Apodaca G. Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway. EMBO J. 2010 Jun 16;29(12):1961-75. Epub 2010 May 11. PubMed PMID:20461056.

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Yu W, Hill WG, Apodaca G, Zeidel ML. Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am J Physiol Renal Physiol. 2011 Jan;300(1):F49-59. Epub 2010 Oct 13. PubMed PMID: 20943764

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Reviews & Book Chapters __________________________________________________________________________________________________________________________________

Apodaca G. Endocytic traffic in polarized epithelial cells: role of the actin and microtubule cytoskeleton. Traffic. 2001 Mar;2(3):149-59. Review. PubMed PMID: 11260520.

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Apodaca G. Modulation of membrane traffic by mechanical stimuli. Am J Physiol Renal Physiol. 2002 Feb;282(2):F179-90. Review. PubMed PMID: 11788431.

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Rojas R, Apodaca G. Immunoglobulin transport across polarized epithelial cells. Nat Rev Mol Cell Biol. 2002 Dec;3(12):944-55. Review. PubMed PMID: 12461560.

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Traub LM, Apodaca G. AP-1B: polarized sorting at the endosome. Nat Cell Biol. 2003 Dec;5(12):1045-7. PubMed PMID: 14647300.

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Apodaca G. The uroepithelium: not just a passive barrier. Traffic. 2004 Mar;5(3):117-28. Review. PubMed PMID: 15086788.

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Apodaca G. Synaptotagmins: mediators of Ca2+-regulated vesicle fusion. Focus on "stable gene silencing of synaptotagmin I in rat PC12 cells inhibits Ca2+-evoked release of catecholamine". Am J Physiol Cell Physiol. 2006 Aug;291(2):C234-6. Epub 2006 May 31. PubMed PMID: 16738005.

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Apodaca G, Balestreire E, Birder LA. The uroepithelial-associated sensory web. Kidney Int. 2007 Nov;72(9):1057-64. Epub 2007 Aug 1. Review. PubMed PMID: 17667988.

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Oztan A, Rondanino C, Apodaca G. Transcytosis of polymeric immunoglobulin a in polarized Madin-Darby canine kidney cells. Methods Mol Biol. 2008;440:157-70. PubMed PMID: 18369944; PubMed Central PMCID: PMC2603048.

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Birder, LA, DeGroat, WC, Apodaca, G. Physiology of the urothelium. In Textbook of the Neurogenic Bladder, 2nd edition, J. Corcos and E. Schick, Eds. Informa Healthcare, London, G.B. 2008, pp 19-39.

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Khandelwal P, Abraham SN, Apodaca G. Cell biology and physiology of the uroepithelium. Am J Physiol Renal Physiol. 2009 Dec;297(6):F1477 501. Epub 2009 Jul 8. Review. PubMed PMID: 19587142; PubMed Central PMCID: PMC2801337

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Apodaca G. Opening ahead: early steps in lumen formation revealed. Nat Cell Biol. 2010 Nov;12(11):1026-8. PubMed PMID: 21045801.

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